Nuclear Translocation of a Key Regulator of Glycolysis: 6-phosphofructo-2-kinase (pfkfb3)
نویسندگان
چکیده
PROLIFERATION VIA CYCLIN-DEPENDENT KINASES Abdullah Yalcin, Brian F. Clem, Alan Simmons, Andrew Lane, Kristin Nelson, Amy L. Clem, Erin Brock, Deanna Siow, Binks Wattenberg, Sucheta Telang and Jason Chesney Division of Medical Oncology (Molecular Targets Group), James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202 Department of Biochemistry, School of Veterinary Medicine, Uludag University, Bursa, Turkey. Running Head: Nuclear 6-Phosphofructo-2-Kinase (PFKFB3) Activity Address Correspondence to: Jason Chesney, MD PhD, Division of Medical Oncology, James Graham Brown Cancer Center, University of Louisville, 580 South Preston Street, #204E, Louisville, Kentucky 40202, Tel. 502 852-3402; Fax 502 852-3661; E-Mail: [email protected]
منابع مشابه
Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib
Background In human cancers, loss of PTEN, stabilization of hypoxia inducible factor-1a, and activation of Ras and AKT converge to increase the activity of a regulator of glycolysis, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3). This enzyme synthesizes fructose-2,6-bisphosphate (F2,6BP), which is an activator of 6-phosphofructo1-kinase, a key step of glycolysis that is tightly ...
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6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), is a critical enzyme for glycolysis and highly expressed in cancer cells. It plays an essential role in regulating metabolism, angiogenesis, and inflammation. Although PFKFB3 is involved in modulating autophagy, its regulatory role appears to be either positive or negative, which remains to be clarified. Unlike other PFK-2...
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Background The family of 6-phospofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) control glycolytic flux via their product, fructose-2,6-bisphosphate (F26BP), which activates the key control step, 6-phosphofructo-1-kinase (PFK-1). We recently demonstrated that exposure of estrogen receptor (ER)+ MCF-7 human breast cancer cells to estradiol (E2) causes a rapid increase in C-glucose uptak...
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PFKFB (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is extensively involved in cell proliferation owing to its key role in carbohydrate metabolism. In the present study we analyse its mechanism of regulation by progestins in breast cancer...
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6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase) catalyzes the synthesis and degradation of fructose 2,6-bisphosphate (F2,6BP), which is a powerful activator of 6-phosphofructo-1-kinase, the rate-limiting enzyme of glycolysis. Four genes encode PFK-2/FBPase (PFKFB1-4), and an inducible isoform (iPFK-2/PFKFB3) has been found to mediate F2,6BP production in proliferating cells....
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